Welcome to the Shen Lab

Research interest​

​

Our lab aims to establish causal, in vivo mechanisms by which microenvironmental (niche) cues regulate adult stem/progenitor cells. We focus on extracellular signals and tissue-level context, and we prioritize quantitative and functional tests over correlative observations.

Across these themes, we start from in vivo biology and seek generalizable, physiologically meaningful rules—, prioritizing causal mechanisms and quantitative readouts over purely correlative descriptions.

• Theme 1 — Growth factors and ECM as instructive niche cues;

• Theme 2 — Microenvironmental control of regeneration;

• Theme 3 — Mechanistic and quantitative in vivo interrogation

 

​

Recent publications​

​

1.  Deep imaging of LepR  stromal cells in optically cleared murine bone hemisections. 

Yuehan Ni*, Jiamiao Wu*, Fengqi Liu, Yating Yi, Xiangjiao Meng, Xiang Gao, Luyi Xiao, Weiwei Zhou, Zexi Chen, Peng Chu, Dan Xing, Ye Yuan, Donghui Ding, Ge Shen, Min Yang, Ronjie Wu, Ling Wang, Luiza Martins Nascentes Melo, Sien Lin, Xiaoguang Cheng, Gang Li, Alpaslan Tasdogan, Jessalyn M. Ubellacker, Hu Zhao#, Shentong Fang# & Bo Shen#.

Bone Research. 2025 Jan;13(1):6. PMID: 39800733.​​

​

2.  Leptin receptor  cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor. 

Xiang Gao, Malea M. Murphy, James G. Peyer, Yuehan Ni, Min Yang, Yixuan Zhang, Jiaming Guo, Nergis Kara, Claire Embree, Alpaslan Tasdogan, Jessalyn M. Ubellacker, Genevieve M. Crane, Shentong Fang, Zhiyu Zhao, Bo Shen#, Sean J. Morrison#.

Nature Cell Biology. 2023 Dec;25(12):1746-1757. PMID: 38012403.

​​​

3.  A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis.  

Bo Shen, Alpaslan Tasdogan, Jessalyn M Ubellacker, Jingzhu Zhang, Elena D Nosyreva, Liming Du, Malea M Murphy, Shuiqing Hu, Yating Yi, Nergis Kara, Xin Liu, Shay Guela, Yuemeng Jia, Vijayashree Ramesh, Claire Embree, Evann C Mitchell, Yunduo C Zhao, Lining A Ju, Zhao Hu, Genevieve M Crane, Zhiyu Zhao, Ruhma Syeda, Sean J Morrison.

Nature. 2021 Mar;591(7850):438-444. PMID: 33627868.​​​

 

View All Publications 

​