Publications

*: co-first authors

#: co-corresponding authors

Year 2023

1. Leptin receptor+ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor.

Xiang Gao, Malea M. Murphy, James G. Peyer, Yuehan Ni, Min Yang, Yixuan Zhang, Jiaming Guo, Nergis Kara, Claire Embree, Alpaslan Tasdogan, Jessalyn M. Ubellacker, Genevieve M. Crane, Shentong Fang, Zhiyu Zhao, Bo Shen#, Sean J. Morrison#.

Nature Cell Biology. 2023 Dec;25(12):1746-1757.PMID: 38012403.

2. Integrin β3 directly inhibits the Gα13-p115RhoGEF interaction to regulate G protein signaling and platelet exocytosis.

Yaping Zhang*, Xiaojuan Zhao*, Bo Shen*, Yanyan Bai, Claire Chang, Aleksandra Stojanovic, Can Wang, Andrew Mack, Gary Deng, Randal A Skidgel, Ni Cheng, Xiaoping Du.

Nature Communications. 2023 Aug 16;14(1):4966. PMID: 37587112.

3. A Novel Computational Biomechanics Framework to Model Vascular Mechanopropagation in Deep Bone Marrow.

Yunduo Charles Zhao, Yingqi Zhang, Fengtao Jiang, Chi Wu, Boyang Wan, Ruhma Syeda, Qing Li, Bo Shen, Lining Arnold Ju. Advanced Healthcare Materials. 2023 Mar;12(8):e2201830. PMID: 36521080.

4. Molecular dissection of somatic skeletal disease in Neurofibromatosis Type 1.

Nandina Paria, Aysha Khalid, Bo Shen, Ben Lemoine, Jinyan Chan, Yared H Kidane, Ila Oxendine, Reuel Cornelia, Carol A Wise, Jonathan J Rios.

Journal of Bone and Mineral Research. 2023 Feb;38(2):288-299. PMID: 36459048.

Year 2022

5. Response of Gli1+ Suture Stem Cells to Mechanical Force Upon Suture Expansion.

Dian Jing, Zexi Chen, Yi Men, Yating Yi, Yuhong Wang, Jun Wang, Jianru Yi, Lingyun Wan, Bo Shen, Jian Q Feng, Zhihe Zhao, Hu Zhao, Chaoyuan Li.

Journal of Bone and Mineral Research. 2022 Jul;37(7):1307-1320. PMID: 35443291.

Prior to 2021 Sep

6. Niches that regulate stem cells and hematopoiesis in adult bone marrow.

Stefano Comazzetto*, Bo Shen*, Sean J Morrison.

Developmental Cell, 2021 Jul 12;56(13):1848-1860. PMID: 34146467.

7. Parathyroid hormone promotes osteogenesis partly by promoting Osteolectin expression.

Jingzhu Zhang, Adi Cohen, Bo Shen, Liming Du, Alpaslan Tasdogan, Zhiyu Zhao, Elizabeth J Shane, Sean J Morrison.

Proceedings of the National Academy of Sciences. 2021 Jun 22;118(25):e2026176118. PMID: 34140410.

8. A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis.

Bo Shen, Alpaslan Tasdogan, Jessalyn M Ubellacker, Jingzhu Zhang, Elena D Nosyreva, Liming Du, Malea M Murphy, Shuiqing Hu, Yating Yi, Nergis Kara, Xin Liu, Shay Guela, Yuemeng Jia, Vijayashree Ramesh, Claire Embree, Evann C Mitchell, Yunduo C Zhao, Lining A Ju, Zhao Hu, Genevieve M Crane, Zhiyu Zhao, Ruhma Syeda, Sean J Morrison. Nature. 2021 Mar;503:131. PMID: 33627868.

9. Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target.

Hanjing Wei, Yanhua Xu, Yibin Wang, Liting Xu, Chunyang Mo, Liangzi Li, Bo Shen, Yao Sun, Pengzhen Cheng, Liu Yang, Yichuan Pang, An Qin, Ying Cao, Sean J Morrison, Rui Yue.

Cell Reports. 2020 Oct 13;33(2):108252. PMID: 33053358.

10. Gli1+ periodontium stem cells are regulated by osteocytes and occlusal force.

Yi Men, Yuhong Wang, Yating Yi, Dian Jing, Wenjing Luo, Bo Shen, William Stenberg, Yang Chai, Woo-Ping Ge, Jian Q Feng, Hu Zhao.

Developmental Cell. 2020 Sep 14;54(5):639-654.e6. PMID: 32652075.

11. Lymph protects metastasizing melanoma cells from ferroptosis.

Jessalyn M Ubellacker, Alpaslan Tasdogan, Vijayashree Ramesh, Bo Shen, Evann C Mitchell, Misty S Martin-Sandoval, Zhimin Gu, Michael L McCormick, Alison B Durham, Douglas R Spitz, Zhiyu Zhao, Thomas P Mathews, Sean J Morrison.

Nature. 2020 Sep;585(7823):113-118. PMID: 32814895.

12. Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles.

Xiaofei Gao, Zhaohuan Zhang, Tomoyuki Mashimo, Bo Shen, James Nyagilo, Hao Wang, Yihui Wang, Zhida Liu, Aditi Mulgaonkar, Xiao-Ling Hu, Sara GM Piccirillo, Ugur Eskiocak, Digant P Davé, Song Qin, Yongjie Yang, Xiankai Sun, Yang-Xin Fu, Hui Zong, Wenzhi Sun, Robert M Bachoo, Woo-ping Ge.

Cell Reports. 2020 Feb 25;30(8):2489-2500.e5. PMID: 32101730.

13. Metabolic heterogeneity confers differences in melanoma metastatic potential.

Alpaslan Tasdogan, Brandon Faubert, Vijayashree Ramesh, Jessalyn M Ubellacker, Bo Shen, Ashley Solmonson, Malea M Murphy, Zhimin Gu, Wen Gu, Misty Martin, Stacy Y Kasitinon, Travis Vandergriff, Thomas P Mathews, Zhiyu Zhao, Dirk Schadendorf, Ralph J DeBerardinis#, Sean J Morrison#.

Nature. 2020 Jan;577(7788):115-120. PMID: 31853067.

14. Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass.

Bo Shen, Kristy Vardy, Payton Hughes, Alpaslan Tasdogan, Zhiyu Zhao, Rui Yue, Genevieve M Crane, Sean J Morrison. eLife. 2019 Jan 11;8:e42274. PMID: 30632962.

15. Clec11a is an osteogenic factor that promotes the maintenance of the adult skeleton.

Rui Yue, Bo Shen, Sean J Morrison.

eLife. 2016 Dec 13;5:e18782. PMID: 27976999.

16. Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis.

M Keegan Delaney, Kyungho Kim, Brian Estevez, Zheng Xu, Aleksandra Stojanovic-Terpo, Bo Shen, Masuko Ushio-Fukai, Jaehyung Cho, Xiaoping Du.

Arteriosclerosis, thrombosis, and vascular biology. 2016 May;36(5):846-54. PMID: 26988594.

17. Signaling-Mediated Cooperativity between Glycoprotein Ib-IX and Protease-Activated Receptors in Thrombin-Induced Platelet Activation.

Brian Estevez, Kyungho Kim, M Keegan Delaney, Aleksandra Stojanovic-Terpo, Bo Shen, Changgeng Ruan, Jaehyung Cho, Zaverio M Ruggeri, Xiaoping Du.

Blood. 2016 Feb 4;127(5):626-36. PMID: 26585954.

18. The interaction of Galpha13 with integrin beta1 mediates cell migration by dynamic regulation of RhoA.

Bo Shen, Brian Estevez, Zheng Xu, Barry Kreutz, Andrei Karginov, Yanyan Bai, Feng Qian, Urao Norifumi, Deane Mosher, Xiaoping Du.

Molecular biology of the cell. 2015 Oct 15;26(20):3658-70. PMID: 26310447.

19. Targeting Integrin and Integrin Signaling in Treating Thrombosis.

Brian Estevez, Bo Shen, Xiaoping Du.

Arteriosclerosis, thrombosis, and vascular biology. 2015 Jan;35(1):24-9. PMID: 25256236.

20. Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism.

Michael Keegan Delaney, Junling Liu, Kyungho Kim, Bo Shen, Aleksandra Stojanovic-Terpo, Yi Zheng, Jaehyung Cho, Xiaoping Du.

Blood. 2014 Sep 18;124(12):1957-67. PMID: 25079357.

21. A directional switch of integrin signalling and a new anti-thrombotic strategy.

Bo Shen, Xiaojuan Zhao, Kelly A O’Brien, Aleksandra Stojanovic-Terpo, M Keegan Delaney, Kyungho Kim, Jaehyung Cho, Stephen C-T Lam, Xiaoping Du.

Nature. 2013 Nov 7;503(7474):131-5. PMID: 24162846.

22. Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction.

Bo Shen, M Keegan Delaney, Xiaoping Du.

Current opinion in cell biology. 2012 Oct;24(5):600-6. PMID: 22980731.

23. VEGF, Bcl-2 and Bad regulated by angiopoietin-1 in oleic acid induced acute lung injury.

Qiang Guo, Jun Jin, Jason X-J Yuan, Amy Zeifman, Bo Shen, Jianan Huang.

Biochemical and biophysical research communications. 2011 Oct 7;413(4):630-6. PMID: 21939637.

23. G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling.

Haixia Gong, Bo Shen, Panagiotis Flevaris, Christina Chow, Stephen C-T Lam, Tatyana A Voyno-Yasenetskaya, Tohru Kozasa, Xiaoping Du.

Science. 2010 Jan 15;327(5963):340-3. PMID: 20075254.